Undesirable effects are ranked under headings of frequency using the following convention: Very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000).
Immune system disorders: Very Rare: Hypersensitivity reactions ranging from cutaneous hypersensitivity to rare cases of anaphylaxis.
Nervous system disorders: Common: Tingling. This is usually of short duration, may be severe and may affect any part of the body including the chest or throat. Dizziness and drowsiness.
Eye disorders: Uncommon: Visual disturbance.
Cardiac disorders: Not known: Bradycardia, tachycardia, palpitations.
Very Rare: Coronary artery vasospasm, transient ischaemic ECG changes, angina and myocardial infarction have been reported very rarely (see Contraindications and Precautions).
Vascular disorders: Very rare: Peripheral vascular ischaemia.
Gastrointestinal: Common: Nausea and vomiting.
Very Rare: Ischaemic colitis.
Skin and subcutaneous tissue disorders: Rare: Rash, Urticaria, Pruritus, facial oedema.
General disorders and administration site conditions: The following symptoms are usually of short duration, may be severe and may affect any part of the body including the chest or throat: Common: Sensations of heat, Malaise/fatigue, Pain.
Uncommon: Sensations of heaviness, pressure or tightness.
Investigations: Uncommon: Increase in blood pressure of approximately 5 mmHg (systolic) and 3 mmHg (diastolic) in a period of up to 12 hours after administration.
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